منابع مشابه
Myocardial no-reflow in humans.
In a variable proportion of patients presenting with ST-segment elevation myocardial infarction, ranging from 5% to 50%, primary percutaneous coronary intervention achieves epicardial coronary artery reperfusion but not myocardial reperfusion, a condition known as no-reflow. Of note, no-reflow is associated with a worse prognosis at follow-up. The phenomenon has a multifactorial pathogenesis in...
متن کاملNo - Reflow
A. DEFINITION. The no-reflow phenomenon was originally observed in experimental models of acute myocardial infarction (MI) and was described as a failure to restore normal myocardial blood flow despite removal of the coronary obstruction. Since that time, no-reflow has been shown to complicate thrombolytic therapy and percutaneous revascularization with PTCA and other devices. Defined angiograp...
متن کاملHyperglycemia and no-reflow phenomenon in acute myocardial infarction.
Phenomenon in Acute Myocardial Infarction Dr. Iwakura and colleagues in a recent issue of the Journal (1) conclude that, from a retrospective analysis of 146 patients, hyperglycemia might be associated with impaired microvascular function after acute myocardial infarction. The investigators describe an independent relation between elevated blood glucose levels on admission and no-reflow phenome...
متن کاملCapillary pericytes mediate coronary no-reflow after myocardial ischaemia
After cardiac ischaemia, a prolonged decrease of coronary microvascular perfusion often occurs even after flow is restored in an upstream artery. This 'no-reflow' phenomenon worsens patient prognosis. In the brain, after stroke, a similar post-ischaemic 'no-reflow' has been attributed to capillary constriction by contractile pericytes. We now show that occlusion of a rat coronary artery, follow...
متن کاملNo-Reflow Phoenomenon by Intracoronary Thrombus in Acute Myocardial Infarction
Recently, percutaneous coronary intervention has been the treatment of choice in most acute myocardial infarction cases. Although the results of percutaneous coronary interventions have ben good, the no-reflow phenomenon and distal embolization of intracoronary thrombus are still major problems even after successful interventions. In this article, we will briefly review the deleterious effects ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2006
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0706863